MOSAIC: MBW and OSC surveillance after stem cell transplant international collaboration
The MOSAIC study (Multiple Breath Washout and Oscillometry Surveillance After stem cell Transplant International Collaboration) is a retrospective individual participant data meta-analysis designed to evaluate lung function in patients who have undergone allogeneic haematopoietic stem cell transplantation (allo-HSCT).
These patients are at risk of developing pulmonary graft-versus-host disease (pGVHD), an obstructive condition affecting the lung periphery that carries high morbidity and mortality, particularly when diagnosed late.
Current diagnostic guidelines rely on spirometry, which is not sensitive to peripheral airway disease. We hypothesise that two novel lung function tests, multiple breath washout (MBW) and oscillometry, can detect early signs of pGVHD, enabling earlier intervention and improved clinical outcomes.
This international collaboration, led by The University of Queensland, aims to compile retrospectively collected individual participant data where MBW and oscillometry were performed as part of a research study or clinical care. Previous single-centre studies lacked sufficient power to assess these tools’ utility. By pooling data across multiple centres, MOSAIC seeks to create the first adequately powered cohort to determine whether MBW and oscillometry can diagnose pGVHD earlier than spirometry.
- To evaluate if pGVHD is associated with peripheral airway function abnormality using MBW and oscillometry and evaluate risk factors associated with the abnormality and pGVHD after allo-HSCT.
- To evaluate and compare the temporal course of the lung function impairment using these MBW and oscillometry with conventional tests (spirometry, lung volumes and diffusing capacity for carbon monoxide) among allo-HSCT recipients.
- To evaluate the utility of MBW and oscillometry at time of pGVHD diagnosis to predict the subsequent clinical course.
- Astrid Lindgren Children’s Hospital, Stockholm
- British Columbia Children’s Hospital, Vancouver
- Great Ormond Street Hospital, London
- Hôpital Foch, Suresnes
- Polytechnic University of Marche, Ancona
- Queen Silvia’s Children’s Hospital, Gothenburg
- Queensland Children’s Hospital, Brisbane
- Rigshospitalet, Copenhagen
- Royal Children’s Hospital, Melbourne
- Royal North Shore Hospital, Sydney
- University Children’s Hospital, Zurich
- University of Toronto, Toronto
- Westmead Children’s Hospital, Sydney
- Wilhelmina Children’s Hospital, Utrecht
- Willem-Alexander Children’s Hospital, Leiden
- Professor Paul Robinson, Coordinating Principal Investigator