Project Title: The Preterm Brain Outcomes (PREBO) Study

Be involved in the largest study of early brain structure and function in preterm infants.

The PreBO study aims to predict neurodevelopmental disability in babies born very preterm, earlier and more accurately than currently possible, by identifying structural and functional connectivity features that correlate with clinical measures of motor and neurodevelopmental functions.

Study Methods

The study will use (i) advanced brain magnetic resonance imaging (MRI) to determine the structural wiring diagram of the brain (‘brain connectome’), (ii) dense array electroencephalography (EEG) to establish the functional activity or electrical ‘traffic’ being carried on the main branches of the connectome and (iii) structured clinical neurodevelopmental assessments to provide a cutting edge view of the state of brain development. Infants born very preterm (23–31 weeks gestation) are at high risk of neurodevelopmental disability (10% cerebral palsy, 50% learning and behavioural difficulties at school age), which results in costs of several billions of dollars annually in Australia. This research project will be a major advance to better neurodevelopmental outcomes through early prediction and rational use of early interventions. This project is an extension of the current PPREMO study conducted in Queensland.

Who can be involved?

This study seeks babies born preterm and  term. If your baby was born before 31 weeks gestation (preterm) or between 40-42 weeks gestation (term) we would like to discuss with you whether you would like to participate in the study.