Prof Christel Middeldorp has a conjoint appointment with the Child Health Research Centre (CHRC), UQ, and Child and Youth Mental Health Service (CYMHS), Children’s Health Queensland Hospital and Health Service (CHQ HHS). Her research interests involve the role of genetic and other familial influences on the development and persistence of psychopathology across the lifespan. She is the co-PI of the Behavior&Cognition working group of the EAGLE consortium (EArly Genetics and Lifecourse Epidemiology). EAGLE aims to identify genetic variants underlying the development and persistence of childhood psychopathology by using data from population based longitudinal child and adolescent cohorts from over the world. She further investigates associations between parental and offspring psychopathology and the development of these associations over time in a clinical cohort consisting of families with children treated at outpatient psychiatric services, who are followed longitudinally.

Qualifications

MD (Rotterdam, The Netherlands), PhD (Amsterdam, The Netherlands),  Child and adolescent psychiatrist (Amsterdam, The Netherlands)

Research Support

Ongoing

2017-2021 CAPICE: Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe. EU Marie Curie European Training Network €3,100,000.

2011-2017 Genetic influences on stability and change in psychopathology from childhood to young adulthood. The Netherlands Organization for Health Research and Development (ZonMw-TOP 91210020).

Completed

2007-2012 The interplay of genetic and environmental factors in the development of anxious depression in children and adults. The Netherlands Organization for Health Research and Development (ZonMw) – Innovational Research Incentives scheme –VENI grant (91676125), €208.000,-. Role: PI.

2009-2011 Psychopathology in parents of children with a psychiatric disorder. The Netherlands. Foundation for Mental Health (Fonds Psychische Gezondheid 20096398), € 50,000. Role: PI.

Awards

2012 EPA Research Prize in the category: “Clinical psychopathology and refinement of psychiatric diagnostic categories”. The prize is awarded by the European Psychiatric Association (EPA) for the best article of 2011 written by an early career psychiatrist.

2012 Fuller & Scott Early Career award, Behavior Genetics Association

Supervision of PhD students

Completed:

  • Risk factors for childhood problem behavior. Studies in twins and triplets.
  • Keeping focus. A study on attention problems in the gwas era.
  • Developmental genetics of psychopathology.

Current:

  • Psychopathology in families.
  • (Epi)genetic factors in anxiety and traumatic stress related symptoms.

Publications

  1. Nivard MG, Gage GH, Hottenga JJ, Van Beijsterveldt CEM, Baselmans BML, Ligthart L, St Pourcain B, Boomsma DI, Munafò MR, Middeldorp CM. Genetic overlap between schizophrenia and developmental psychopathology: longitudinal and multivariate polygenic risk prediction of common psychiatric traits during development. Schizophrenia Bulletin, in press.
  2. Culverhouse RC, Saccone N, Horton A,….Middeldorp CM…..Goate A. Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular Psychiatry, in press.
  3. Wesseldijk LW, Fedko IO, Bartels M, Nivard MG, Van Beijsterveldt CEM, Boomsma DI, Middeldorp CM. Psychopathology in 7-year-old children: differences in maternal and paternal ratings and the genetic epidemiology. American Journal of Medical Genetics part B, in press.
  4. Nivard MG, Lubke GH, Dolan CV, Evans DM, St Pourcain B, Munafo MR, Middeldorp CM. Joint developmental trajectories of internalizing and externalizing disorders between childhood and adolescence. Development and Psychopathology, in press.
  5. Molenaar D, Middeldorp CM, Vink JM, Willemsen G, Ligthart L, Dolan CV, Nivard MG, Boomsma DI. Evidence for genotype by environment interaction in adult depression in a large sample of twins. Behavior Genetics, in press
  6. Bot M, Middeldorp CM, De Geus EJC, Lau HM, Sinke M, Van Nieuwenhuizen B, Smit JH, Boomsma DI, Penninx BWJH. Validity of LIDAS: a self-report online assessment of lifetime major depressive disorder. Psychological Medicine, 2017, 47:279-289.
  7. Fedko IO, Wesseldijk LW, Nivard MG, Hottenga JJ, Van Beijsterveldt CEM, Middeldorp CM, Bartels M, Boomsma DI. Heritability of behavioral problems in 7-year olds based on shared and unique aspects of parental views. Behavior Genetics, 2017, 47:152-163.
  8. Lee M, Aggen SH, Otowa T, Castelao E, Preisig M, Grabe HJ, Hartman CA, Oldehinkel AJ, Middeldorp CM, Tiemeier H, Hettema JM. Assessment and characterization of phenotypic heterogeneity of anxiety disorders across five large cohorts. International Journal of Methods in Psychiatric Research, 2016, 255-266.
  9. Nivard MG, Middeldorp CM, Lubke GH, Hottenga JJ, Abdellaoui A, Boomsma DI, Dolan CV. Detection of gene -environment interaction in pedigree data using genome-wide genotypes. European Journal of Human Genetics, 2016, 24:1803-1809.
  10. Hinney A, Kesselmeier M, .., EGG, .. Hebebrand J. Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Mol Psychiatry, 2016, 192-201.
  11. Power RA, Tansey KE, .., McIntosh AM, Middeldorp CM, ,…Breen G, Lewis CM. Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Biological Psychiatry, 2017, 81: 325-335.
  12. Middeldorp CM, Hammerschlag AR, Ouwens KG, …, Tiemeier H, Posthuma D, Boomsma DI. A genome-wide association meta-analysis of ADHD symptoms in population-based paediatric cohorts, Journal of the American Academy of Child and Adolescent Psychiatry, 2016, 55:896-905.
  13. Middeldorp CM, Wesseldijk LW, Lindauer RJL, Hudziak JJ, Verhulst FC, Dieleman GC. Parents of children with psychopathology: psychiatric problems and the association with their children’s problems. European Child and Adolescent Psychiatry, 2016; 25:919-927.
  14. Lubke GH, Miller P, Verhulst B, Bartels M, Van Beijsterveldt CEM, Willemsen G, Boomsma DI, Middeldorp CM. A powerful phenotype for gene-finding studies derived from trajectory analyses of symptoms of anxiety and depression between age seven and 18. American Journal of Medical Genetics Part B, 2016; 171: 948-957.
  15. Otowa T, Hek K, …, Middeldorp CM, Penninx BW, Boomsma D, Martin NG, Montgomery G, Maher BS, van den Oord EJ, Wray NR, Tiemeier H, Hettema JM. Meta-analysis of genome-wide association studies of anxiety disorders. Mol Psychiatry, 2016; 21:1391-1399.
  16. Porsch RM, Middeldorp CM, Cherny S, Krapohl E, Van Beijsterveldt E, Loukola A, Korhonen T, Pulkinnen L,  Corley R, Rhee S, Kaprio J, Rose RR, Hewitt JK, Sham P, Plomin R, Boomsma DI, Bartels M. Longitudinal Heritability of Childhood Aggression. American Journal of Medical Genetics Part B, 2016;171: 697-707
  17. Hagenbeek FA, Kluft C, Hankemeier T, Bartels M, Draisma HHM, Middeldorp CM, Berger R, Noto A, Lussu M, Pool R, Fanos V, Boomsma DI. Discovery of biochemical biomarkers for aggression: a role for metabolomics in psychiatry. American Journal of Medical Genetics Part B, 2016;171: 719-732.
  18. Pappa I, St Pourcain B … Middeldorp CM, …Tiemeier H. A Genome-Wide Approach to Children’s Aggressive Behavior. The EAGLE consortium. American Journal of Medical Genetics Part B, 2016; 171: 562-572.
  19. Wesseldijk LW, Dieleman GC, Lindauer RJL, Bartels M, Willemsen G, Hudziak JJ, Boomsma DI, Middeldorp CM. Spousal resemblance in psychopathology: A comparison of parents of children with and without psychopathology. European Psychiatry, 2016;34: 49-55.
  20. Felix JF, Bradfield JP…, Middeldorp CM, …, Sørensen TI, Timpson NJ, Grant SF, Jaddoe VW; Early Growth Genetics (EGG) Consortium; Bone Mineral Density in Childhood Study BMDCS. Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics. 2016;25: 389-403.
  21. EArly Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium, Australian Asthma Genetics Consortium(AAGC). Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nature Genetics, 2015; 47: 1449-1456.
  22. Nivard MG, Middeldorp CM, Dolan CV, Boomsma DI. Genetic and environmental stability of neuroticism from adolescence to adulthood. Twin Research and Human Genetics, 2015; 18: 746-54.
  23. Molenaar D, Middeldorp CM, Van Beijsterveldt CEM, Boomsma DI. Analysis of Behavioral and Emotional Problems in Children Highlights the Role of Genotype x Environment Interaction. Child Development, 2015, 86: 1999-2016.
  24. Fedko IO, Hottenga JJ, Medina-Gomez C, Pappa I, Van Beijsterveldt CEM, Ehli EA, Davies GE, Rivadeneira F, Tiemeier H, Swertz MA, Middeldorp CM, Bartels M, Boomsma DI. Estimation of genetic relationships between individuals across cohorts and platforms: application to childhood height. Behavior Genetics, 2015, 45: 514-528.
  25. Pappa I, Fedko I, Mileva-Seitz VR, Hottenga JJ, Bakermans-Kranenburg MJ, Bartels M, Van Beijsterveldt CEM, Jaddoe VWV, Middeldorp CM, Rippe RCA, Rivadeneira F, Tiemeier H, Verhulst FC, Van IJzendoorn MH, Boomsma DI. Single Nucleotide Polymorphism heritability of behavior problems in childhood: Genome-Wide Complex Trait Analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 2015, 54: 737-744.
  26. Arloth J, Bogdan R, Weber P, Frishman G, Menke A, Wagner KV, Balsevich G, Schmidt MV, Karbalai N, Czamara D, Altmann A, Trümbach D, Wurst W, Mehta D, Uhr M, Klengel T, Erhardt A, Carey CE, Conley ED; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), Ruepp A, Müller-Myhsok B, Hariri AR, Binder EB; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium PGC. Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders. Neuron. 2015, 86: 1189-1202.
  27. Treur JL, Vink JM, Boomsma DI, Middeldorp CM. Spousal resemblance for smoking: underlying mechanisms and effects of cohort and age. Drug and Alcohol Dependence, 2015, 153: 221-228.
  28. Peyrot WJ, Lee SH, … Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium (Corporate Collaborator), … Wray NR, Penninx BW. The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects. Molecular Psychiatry. 2015, 20: 735-743.
  29. Byrne EM; Psychiatric Genetics Consortium Major Depressive Disorder Working Group, Raheja K, Stephens SH, Heath AC, Madden PA, Vaswani D, Nijjar GV, Ryan KA, Youssufi H, Gehrman PR, Shuldiner AR, Martin NG, Montgomery GW, Wray NR, Nelson EC, Mitchell BD, Postolache TT. Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder. Journal of Clinical Psychiatry. 2015, 76:128-34.
  30. The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience, 2015, 18: 199-209.
  31. Maier R, Moser G, Chen GB, Ripke S; Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Coryell W, Potash JB, Scheftner WA, Shi J, Weissman MM, Hultman CM, Landén M, Levinson DF, Kendler KS, Smoller JW, Wray NR, Lee SH; Cross-Disorder Working Group of the Psychiatric Genomics Consortium. Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. American Journal of Human Genetics. 2015; 96:283-94.
  32. Nivard MG, Dolan CV, Kendler KS, Kan K-J, Willemsen G, Van Beijsterveldt CEM, Lindauer RJL, Van Beek JHDA, Geels LM, Bartels M, Middeldorp CM*, Boomsma DI*. *Shared last. Stability in symptoms of anxiety and depression as a function of genotype and environment: A longitudinal twin study from age 3 to 63 years. Psychological Medicine, 2015; 45:1039-49.
  33. Perry JR, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI, Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines Cohort Study; InterAct Consortium; Early Growth Genetics (EGG) Consortium, Widen E, Zygmunt M, Murray A, Easton DF, Stefansson K, Murabito JM, Ong KK. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature. 2014; 514:92-7.
  34. Lindauer RJ, Brilleslijper-Kater SN, Diehle J, Verlinden E, Teeuw AH, Middeldorp CM, Tuinebreijer W, Bosschaart TF, Van Duin E, Verhoeff A. The Amsterdam Sexual Abuse Case (ASAC)-study in day care centers: longitudinal effects of sexual abuse on infants and very young children and their parents, and the consequences of the persistence of abusive images on the internet. BMC Psychiatry, 2014; 14:295.
  35. Groen-Blokhuis MM, Middeldorp CM, Kan K-J, Abdellaoui A, Van Beijsterveldt CEM, Ehli EA, Davies GE, Scheet PA, Xiao X, Hudziak JJ, Hottenga JJ, Psychiatric Genomics Consortium ADHD Working Group, Neale BM, Boomsma DI. Attention Deficit Hyperactivity Disorder polygenic risk scores predict Attention Problems in a population-based sample of children. Journal of the American Academy of Child and Adolescent Psychiatry, 2014; 53: 1123-1129.
  36. Cousminer DL, Stergiakouli E, ….Middeldorp CM, …. McCarthy MI, Widén E; for the Early Growth Genetics (EGG) Consortium. Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. Human Molecular Genetics, 2014; 23:4452-4464.
  37. Wray NR, Lee SH, Mehta D, Vinkhuyzen AAE, Dudbridge F, Middeldorp CM. Polygenic methods and their application to psychiatric traits. Journal of Child Psychology and Psychiatry, 2014;55: 1068-1087
  38. Benke KS, Nivard MG, Velders FP, Walters RK, Scheet PA, Xiao X, Ehli EA, Palmer LJ, Whitehouse AJO, Verhulst FC, Jaddoe VW, Rivadeneira F, Groen-Blokhuis MM, van Beijsterveldt CEM, Davies GE, Hudziak JJ, Lubke GH, Boomsma DI, Pennell CE, Tiemeier H, Middeldorp CM for the EAGLE consortium. A genome-wide association meta-analysis of Preschool Internalizing Problems. Journal of the American Academy for Child and Adolescent Psychiatry, 2014;53: 667-676.
  39. Middeldorp CM, Lamb DJ, Vink JM, Bartels M, Van Beijsterveldt CEM, Boomsma DI. Child care, socio-economic status and problem behavior: a study of gene-environment interaction in young Dutch twins. Behavior Genetics, 2014;44: 314-325.
  40. Wright FA, Sullivan PF, .... Middeldorp CM, ..... Penninx BWJH, Boomsma DI. Heritability and genomics of gene expression in peripheral blood. Nature Genetics, 2014;46:430-437.
  41. Nivard MG, Mbarek H, Hottenga JJ, Smit JH, Jansen R, Penninx BW, Middeldorp CM, Boomsma DI. Further confirmation of the association between anxiety and CTNND2: replication in humans. Genes Brain & Behavior. 2014;13:195-201.
  42. Ligthart L, Hottenga JJ, Lewis CM, Farmer AE, Craig IW, Breen G, Willemsen G, Vink JM, Middeldorp CM, Byrne EM, Heath AC, Madden PAF, Pergadia ML, Montgomery GW, Martin NG, Penninx BWJH, McGuffin P, Boomsma DI, Nyholt DR. Polygenic score analysis indicates migraine with and without comorbid depression are genetically different disorders. Human genetics, 2014;133:173-186.
  43. Culverhouse RC, Bowes L, Breslau N, Nurnberger JI Jr, Burmeister M, Fergusson DM, Munafò M, Saccone NL, Bierut LJ; 5-HTTLPR, Stress, and Depression Consortium. Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression. BMC Psychiatry, 2013;13:304.
  44. Cousminer DL, Berry DJ, Timpson NJ, … Hyppönen E, Järvelin MR, McCarthy MI, Ripatti S, Widén E; EAGLE Consortium. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Human Molecular Genetics. 2013;22:2735-2747.
  45. Groen-Blokhuis MM, Franic S, Van Beijsterveldt CEM, De Geus E, Davies G, Ehli E, Xiao X, Scheet P, Bartels M, Hudziak JJ, Middeldorp CM*, Boomsma DI*. *Shared senior authorship. A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and attention problems. American Journal of Medical Genetics Part B, 2013; 162B:457-465.
  46. Brandys MK, Kas MJ, van Elburg AA, Ophoff R, Slof-Op't Landt MC, Middeldorp CM, Boomsma DI, van Furth EF, Slagboom PE, Adan RA. The Val66Met polymorphism of the BDNF gene in anorexia nervosa: New data and a meta-analysis. World Journal of Biological Psychiatry, 2013;14:441-451.
  47. Cross-Disorder Group of the Psychiatric Genomics Consortium. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics, 2013;45:984-994.
  48. Cross-Disorder Group of the Psychiatric Genomics Consortium, Smoller JW,Craddock N, Kendler K, Lee PH, Neale BM, Nurnberger JI, Ripke S, Santangelo S,Sullivan PF. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet, 2013: 381:1371-9.
  49. Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium. A Mega-analysis of Genome-Wide Association Studies for major depressive disorder. Molecular Psychiatry, 2013; 18: 497-511.
  50. Peyrot WJ, Middeldorp CM, Jansen R, Smit JH, De Geus EJC, Hottenga JJ, Willemsen G, Vink JM, Virding S, Barragan I, Ingelsman-Lundberg M, Sim SC, Boomsma DI, Penninx BWJH. Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR Polymorphisms in a large Dutch sample. Journal of affective disorders. 2013;146:91-99.
  51. Kan K-J, Dolan CV, Nivard MG, Middeldorp CM, Van Beijsterveldt CEM, Willemsen G, Boomsma DI. Genetic and Environmental Stability in Attention Problems Across the Lifespan: Evidence From the Netherlands Twin Register. Journal of the American Academy of Child and Adolescent Psychiatry. 2013;52:12-25.
  52. Van Beijsterveldt CEM, Groen-Blokhuis MM, Hottenga JJ, Franić S, Hudziak JJ, Lamb DJ, Huppertz C, De Zeeuw E, Nivard MG, Schutte N, Swagerman S, Glasner T, Van Fulpen M, Brouwer C, Stroet T, Nowotny D, Ehli EA, Davies GE, Scheet PE, Orlebeke JF, Kan KJ, Smit DJ, Dolan CV, Middeldorp CM, De Geus EJC, Bartels M, Boomsma DI. The Young Netherlands Twin Registry (YNTR): Longitudinal twin and family studies in over 70,000 children. Twin Research and Human Genetics, 2013;16:252-267.
  53. Slof-Op ‘t Landt MCT, Bartels M, Middeldorp CM, Van Beijsterveldt CEM, Slagboom PE, Boomsma DI, Van Furth EF, Meulenbelt I. Genetic variation at the TPH2 gene influences impulsivity in addition to eating disorders. Behavior Genetics. 2013;43:24-33.
  54. Geels LM, Groen-Blokhuis MM, Van Beijsterveldt TCEM, Vink JM, Middeldorp CM, Bartels M, Davies G, Ehli E, Boomsma DI. Maternal prenatal smoking and offspring emotional problems: No moderating effect of maternal or child 5-HTTLPR genotype. American Journal of Medical Genetics Part B. 2012;159B:1009-12.
  55. Vink JM, Bartels M, Van Beijsterveldt T, Van Dongen J, Van Beek JHDA, Distel MA, De Moor MHM, Smit DJA, Minica CC, Ligthart RSL, Geels LM, Abdellaoui A, Middeldorp CM, Hottenga JJ, Willemsen G, De Geus EJC, Boomsma DI. Sex differences in Genetic architecture of complex Phenotypes? Plos One. 2012;7:e47371.
  56. Luciano M, Huffman JE, Arias-Vásquez A, Vinkhuyzen AAE, Middeldorp CM, Giegling I, Payton A, Davies G, Zgaga L, Janzing J, Ke X, Galesloot T, Hartmann AM, Ollier W, Tenesa A, Hayward C, Verhagen M, Montgomery GW, Hottenga JJ, Konte B, Starr JM, Vitart V, Vos PE, Madden PAF, Willemsen G, Konnerth H, Horan MA, Porteous DJ, Campbell H, Vermeulen SH, Heath AC, Wright A, Polasek O, Kovacevic SB, Hastie ND, Franke B, Boomsma DI, Martin NG, Rujescu D, Wilson JF, Buitelaar J, Pendleton N, Rudan I, Deary IJ.  Genome-wide association uncovers shared genetic effects among personality traits and mood states. American Journal of Medical Genetics, Part B. 2012;159B:684-695.
  57. Lubke GH, Hottenga JJ, Walters R, Laurin C, De Geus EJC, Willemsen G, Smit JH, Middeldorp CM, Penninx BWJH, Vink JM, Boomsma DI. Estimating the genetic variance of Major Depressive Disorder (MDD) due to all typed SNPs. Biological Psychiatry. 2012;72:707-709.
  58. Webb BT, Guo AY, Maher BS, Zhao Z, Van den Oord EJ, Kendler KS, Riley BP, Gillespie NA, Prescott CA; Middeldorp CM, Willemsen G, De Geus, EJC, Hottenga JJ, Boomsma DI, Slagboom PE, Wray NR, Montgomery GW, Martin NG, Wright MJ, Heath AC, Madden PA, Gelernter J,  Knowles JA, Hamilton SP, Weissman MM, Fyer AJ, Huezo-Diaz P, McGuffin P, Farmer A, Craig IW, Lewis C, Sham P, Crowe RR, Flint J, Hettema JM. Meta-analyses of Genome-wide Linkage Scans of Anxiety Related Phenotypes. European Journal of Human Genetics,2012; 20:1078-1084.
  59. Lamb DJ, Middeldorp CM, Van Beijsterveldt CEM, Boomsma DI. Gene-environment interaction in teacher rated internalizing and externalizing problem behaviour in 7 to 12 year old twins. Journal of Child Psychology and Psychiatry and allied disciplines, 2012;53:818-825.
  60. Lamb DJ, Vink JM, Middeldorp CM, Van Beijsterveldt CE, Haak MC, Overbeek LI, Boomsma DI. Effects of chorionicity and zygosity on triplet birth weight. Twin Research and Human Genetics, 2012;15:149-157.
  61. Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM,Kaakinen M, Kreiner-Møller E, Bradfield JP, Freathy RM, Geller F, Guxens M,Cousminer DL, Kerkhof M, Timpson NJ, Ikram MA, Beilin LJ, Bønnelykke K, Buxton JL, …EAGLE, … Pearson ER, Pennell CE, Price TS, Power C, Raitakari OT, Saw SM, Scherag A, Simell O, Sørensen TI, Timpson NJ, Widen E, Wilson JF. Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 2012;44:532-538.
  62. The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, …EAGLE, … Saw SM, Scherag A, Simell O, Sørensen TI, Wilson JF. Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 2012; 44: 539-544.
  63. Bradfield JP, Taal HR, Timpson NJ, … Jarvelin MR, Jaddoe VW, Smith GD, Hakonarson H, Grant SF; Early Growth Genetics Consortium. A genome-wide association meta-analysis identifies new childhood obesity loci. Nature genetics. 2012; 44:26-31.
  64. Brandys MK, Slof-Op ’t Landt MCT, Van Elburg AA, Ophoff  R, Verduijn W, Meulenbelt I, Middeldorp CM,  Boomsma DI, Van Furth EF, Slagboom PE, Kas MJH, Adan RAH. Anorexia nervosa and the Val/Met polymorphism of the COMT gene: meta-analysis and new data. Psychiatric Genetics, 2012; 22: 130-136.
  65. Wray NR, Pergadia ML, Blackwood DH, Penninx BW, Gordon SD, Nyholt DR, Ripke S, Macintyre DJ, McGhee KA, MacLean AW, Smit JH, Hottenga JJ, Willemsen G, Middeldorp CM, de Geus EJ, Lewis CM, McGuffin P, Hickie IB, van den Oord EJ, Liu JZ, Macgregor S, McEvoy BP, Byrne EM, Medland SE, Statham DJ, Henders AK, Heath AC, Montgomery GW, Martin NG, Boomsma DI, Madden PA, Sullivan PF. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Molecular Psychiatry, 2012, 17: 36-48.
  66. Groen-Blokhuis MM, Middeldorp CM, Van Beijsterveldt CEM, Boomsma DI. Evidence for a causal association of low birth weight and attention problems. Journal of the American Academy of Child and Adolescent Psychiatry, 2011; 50: 1247-1254.
  67. Middeldorp CM, De Moor MHM, McGrath LM, Gordon SD, Blackwood DH, Costa PT, Terracciano A, Krueger RF, De Geus EJC, Nyholt DR, Tanaka R, Esko T, Madden PAF, Derringer J, Amin N, Willemsen G, Hottenga JJ, Distel MA, Uda M, Sanna S, Spinhoven P, Hartman CA, Ripke S, Sullivan PF, Realo A, Allik J, Heath AC, Pergadia ML, Agrawal A, Lin P, Grucza RA, Widen E,  Cousminer DL, Eriksson JG, Palotie A, Barnett JH, Lee PH, Luciano M, Tenesa A, Davies G, Lopez LM, Hansell NK, Medland SE, Ferrucci L, Schlessinger D, Montgomery GW, Wright MJ, Aulchenko YS, Janssens ACJW, Oostra BA, Metspalu A, Abecasis GR, Deary IJ, Räikkönen K, Bierut LJ, Martin NG, Wray NR, Van Duijn CM, Smoller JW, Penninx BWJH, Boomsma DI. The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome wide association data. Translational Psychiatry, 2011; 1: e50.
  68. Kendler KS, Eaves LJ, Loken E, Pedersen N, Middeldorp CM, Reynolds C, Boomsma DI, Lichtenstein P, Silberg J, Gardner CO. The impact of environmental experiences on symptoms of anxiety and depression across the lifespan. Psychological Science, 2011; 22: 1343-1352.
  69. Distel MA, Carlier A, Middeldorp CM, Saviouk V, Lubke GH, Derom CA, Boomsma DI. Borderline personality disorder and attention-deficit hyperactivity disorder: a genetic analysis of comorbidity. American Journal of Medical Genetics part B Neuropsychiatric Genetics, 2011; 156B: 817-825.
  70. Groen-Blokhuis MM, Middeldorp CM, Van Beijsterveldt CEM, Boomsma DI. Crying without a cause and being easily upset in two year olds: heritability and predictive power. Twin Research and Human Genetics, 2011; 14: 393-400.
  71. Demirkan A, Penninx BWJH, Hek K, Wray NR, Amin N, Aulchenko YS, Van Dyck R, De Geus EJC, Hofman A, Uitterlinden AG, Hottenga JJ, Nolen WA, Oostra B, Sullivan PF, Willemsen G, Zitman FG, Tiemeier H, Janssens ACJW, Boomsma DI, Van Duijn CM, Middeldorp CM. Genetic risk profiles for depression and anxiety in adult and elderly cohorts. Molecular Psychiatry, 2011; 16: 773-783.
  72. Distel MA, Middeldorp CM, Trull TJ, Derom CA, Willemsen G, Boomsma DI. Life events and borderline personality: the influence of gene-environment correlation and gene-environment interaction. Psychological Medicine, 2011; 41: 849-860.
  73. Slof-Op ‘t Land MCT, Meulenbelt I, Bartels M, Suchiman E, Middeldorp CM, Houwing-Duistermaat JJ, Van Trier J, Onkenhout EJ, Vink JM, Van Beijsterveldt CEM, Brandys MK, Sanders N, Zipfel S, Herzog W, Herpertz-Dahlman B, Wanrke A, Fleischhaker C, Zeeck A, De Zwaan M, Herpertz S, Ehrlich S, Van Elburg AA, Adan RAH, Scherag S, Hinney A, Hebebrand J, Boomsma DI, Van Furth EF, Slagboom PE. Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting. Genes, Brain &Behavior, 2011; 10: 236-243.
  74. Lamb DJ, Middeldorp CM, Van Beijsterveldt CEM, Vink JM, Haak MC, Boomsma DI. Birth weight in a large series of triplets. BMC Pediatrics, 2011;1: 11-24.
  75. Bartels M, Van de Aa N, Van Beijsterveldt CEM, Middeldorp CM, Boomsma DI. Adolescent self report of emotional and behavioral problems; interactions of genetic factors with sex and age. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 2011; 20: 35-52.
  76. Van Beijsterveldt CEM, Middeldorp CM, Slof-Op ‘t Land MCT. Bartels M, Hottenga JJ, Suchiman HED, Slagboom PE, Boomsma DI. Influence of candidate genes on attention problems in children: a longitudinal study. Behavior Genetics, 2011; 41: 155-164.
  77. Perlis RH, Huang J, Purcell S, Fava M, A. Rush J, Sachs G,  Sullivan PF, Hamilton SP, McMahon FJ, Schulze T, Potash JB, Zandi PP, Willour VL, Penninx BW,  Boomsma DI, Vogelzangs N, Middeldorp CM, Rietschel M, Nöthen M, Cichon S, Gurling H, Bass N, McQuillin A, Hamshere  M, WTCC Bipolar Disorder Grou,  Craddock N, Sklar P, Smoller JW. Genome-wide association study of suicide attempts in mood disorder patients, American Journal of Psychiatry, 2010; 167: 1499-1507
  78. Middeldorp CM, de Geus EJ, Willemsen G, Hottenga JJ, Slagboom PE, Boomsma DI. The Serotonin Transporter Gene Length Polymorphism (5-HTTLPR) and Life Events: No Evidence for an Interaction Effect on Neuroticism and Anxious Depressive Symptoms. Twin Research and Human Genetics. 2010;13: 544-549.
  79. Middeldorp CM, Slof-Op ’t Landt MCT, Medland SE, Van Beijsterveldt CEM, Bartels M, Willemsen G, Hottenga JJ, De Geus EJC, Suchiman HED,  Dolan CV, Neale MC, Slagboom PE, Boomsma DI. Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes. Genes, Brain &Behavior, 2010; 9: 908-916.
  80. Franić S, Middeldorp CM, Dolan CV, Ligthart L, Boomsma DI. Childhood and Adolescent Anxiety and Depression: Beyond Heritability. Journal of the American Academy of Child and Adolescent Psychiatry, 2010; 49: 820-829.
  81. Lamb DJ, Middeldorp CM, Van Beijsterveldt CEM, Bartels M, Polderman TJC, Boomsma DI. Heritability of Anxious/Depressive and Withdrawn Behavior: Age-Related changes during Adolescence. Journal of the American Academy of Child and Adolescent Psychiatry, 2010; 49: 248-255.
  82. Middeldorp CM, Vink JM, Hettema JM, De Geus EJC, Kendler KS, Willemsen G, Neale MC, Boomsma DI, Chen X. An association between Epac-1 gene variants and anxiety and depression in two independent samples. American Journal of Medical Genetics Part B, 2010; 153: 214-219.
  83. Middeldorp CM, Sullivan PF, Wray NR, Hottenga JJ, de Geus EJC, van den Berg M, Montgomery GW, Coventry WL, Statham DJ, Andrews G, Slagboom PE, Boomsma DI, Martin NG. Suggestive linkage on chromosome 2, 8 and 17 for lifetime major depression. American Journal of Medical Genetics Part B, 2009; 150B: 352-358.
  84. Wray NR, Middeldorp CM, Birley AJ, Gordon SD, Sullivan PF, Visscher PM, Willemsen G, De Geus EJC, Slagboom EP, Montgomery GW, Martin NG, Boomsma DI. Genome Wide Linkage Analysis of Multiple Measures of Neuroticism from two large cohorts from Australia and the Netherlands. Archives of general psychiatry, 2008; 65: 649-658.
  85. Middeldorp CM, Cath DC, Beem AL, Willemsen G, Boomsma DI. Life events, anxious depression and personality: a prospective and genetic study. Psychological Medicine, 2008; 38: 1557-1565.

  86. Distel MA, Vink JM, Willemsen G, Middeldorp CM, Merckelbach HL, Boomsma DI.Heritability of Self-reported Phobic Fear. Behavior Genetics, 2008; 38: 24-33.
  87. Shifman S, Bhomra A, Smiley S, Wray NR, James MR, Martin NG, Hettema JM, An SS, Neale MC, van den Oord EJ, Kendler KS, Chen X, Boomsma DI, Middeldorp CM, Hottenga JJ, Slagboom PE, Flint J. A whole genome association study of neuroticism using DNA pooling. Molecular Psychiatry, 2008; 13; 84-89.
  88. Middeldorp CM, Hottenga JJ, Slagboom PE, Sullivan PF, de Geus EJ, Posthuma D, Willemsen G, Boomsma DI. Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype. Molecular Psychiatry, 2008; 13:84-9.
  89. Middeldorp CM, de Geus EJ, Beem AL, Lakenberg N, Hottenga JJ, Slagboom PE, Boomsma DI. Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression. Behavior Genetics, 2007; 37: 294-301.
  90. Middeldorp CM, Wray NR, Andrews G, Martin NG, Boomsma DI. Sex differences in symptoms of depression in unrelated individuals and opposite-sex twin and sibling pairs. Twin Research and Human Genetics, 2006; 9: 632-6.
  91. Middeldorp CM, Cath DC, Boomsma DI. A twin-family study of the association between employment, burnout and anxious depression. Journal of Affective Disorders, 2006; 90: 163-169.
  92. Middeldorp CM, Birley AJ, Cath DC, Gillespie NA, Willemsen G, Statham D, de Geus EJC, Andrews JG, van Dyck R, Beem AL, Sullivan PF, Martin NG, Boomsma DI. Familial clustering of major depression and anxiety disorders in Dutch and Australian sibling pairs. Twin Research and Human Genetics, 2005; 8: 609-615.
  93. Middeldorp CM, Cath DC, Vink JM, Boomsma DI. Twin and genetic effects on life events. Twin Research and Human Genetics, 2005; 8: 224-31.
  94. Middeldorp CM, Cath DC, Van Dyck R, Boomsma DI. The comorbidity of anxiety and depression in the perspective of genetic epidemiology. A review of twin and family studies. Psychological Medicine, 2005; 35: 611-624.
  95. Middeldorp CM, Stubbe JH, Cath DC, Boomsma DI. Familial clustering in burnout. A twin-family study. Psychological Medicine, 2005; 35: 113-120.
  96. Vink JM, Willemsen G, Stubbe JH, Middeldorp CM, Ligthart RS, Baas KD, Dirkzwager HJ, de Geus EJ, Boomsma DI. Estimating non-response bias in family studies: application to mental health and lifestyle. European Journal of Epidemiology, 2004; 19: 623-30.
  97. Middeldorp CM, Arts WFM, Geerts AT, Brouwer OF, Peters ACB, Stroink H, Van Donselaar CA. Nonsymptomatic generalized epilepsy in children younger than six years: excellent prognosis, but classification should be reconsidered after follow-up: the Dutch Study of Epilepsy in Childhood. Epilepsia, 2002; 43:734-9.