Muscle Growth and Botox

A randomised controlled trial of the impact of the first intramuscular Botulinum toxin A (BoNT-A) on muscle structure and function in children with CP.

Chief Investigators

Dr Lee Barber, Prof Roslyn Boyd, Dr Glen Lichtwark (QLD), Prof Catherine Elliott (WA), Prof Kerr Graham (VIC)

About the Study

Background: Botulinum toxin type-A (BoNT-A) is used to reduce spasticity in children with CP, however it can reduce muscle growth and strength. This study uses innovative ultrasound methods (2D/3D) to examine the impact of BoNT-A on calf muscle growth/structure in children with CP naïve to BoNT-A.

Design: Randomised, wait-list controlled, assessor-blinded multi-site trial of BoNT-A of 50 infants with spastic type CP aged 2- 5years (25/25 Rx, Control) and 25 age matched TDC.

Methods: Primary: muscle cross sectional area. Secondary: lower limb anaerobic power, habitual physical activity and participation to determine outcomes.

Recruitment Criteria

We are investigating the shape, size and structure of the calf muscles in children with and without cerebral palsy. We will be using 3D ultrasound to look at your muscles as they grow.

If you have a child with cerebral palsy between the ages of 2 and 5 years, you both could help us.

Contact

Dr Lee Barber, Ph:  +61 7 3069 7334 or E: l.barber@uq.edu.au